![]() The Thermal Amine Scrubber on the International Space Station (ISS) is one of three candidate technologies for CO 2 removal and has been successfully operated in space 7, 8. Liquid amine scrubbing is a mature post-combustion carbon capture technology on Earth 1, 2, 3, 4 and is a promising approach to scrub CO 2 produced during crewed space missions 5, 6, 7, 8. Values from the system complexity metric (SCM), technology readiness level (TRL), integration readiness level (IRL), and degree of crew assistance metric identified a simpler, less costly, and easier to operate design for automated biomass dewatering, cell lysis, and protein affinity purification. Three designs that differed in biomass dewatering and protein purification approaches had nearly equivalent ESM of 357–522 kg eq. Instead, bioprocessing system designs focused on minimizing complexity and enabling system versatility. Non-crew time equivalent system mass (ESM) analyses had limited utility for selecting specific technologies. Design workflows encompassed biomass dewatering of 1 L Escherichia coli cultures through to recombinant protein purification. Here, commercial technologies were assessed to design space bioprocessing systems to supply a liquid amine carbon dioxide scrubber with active carbonic anhydrase produced recombinantly. To advance biomanufacturing, bioprocessing systems need to be developed for space applications. Space-based biomanufacturing has the potential to improve the sustainability of deep space exploration.
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